Determination of Citalopram by RP-HPLC & it’s stability indicative studies
D.Bharath Kumar
, M VENKATESH , Dr.A.Yasodha
Citalopram, RP-HPLC, Method Development, Validation, Accuracy, Precision, Stability
In the present research, Determination of Citalopram by RP-HPLC & it’s stability indicative studies was developed and developed method was validated as per ICH Q2R1 guidelines. The Chromatographic separation was carried out on a Develosil ODS HG-5 RP C18, 5µm, 15cmx4.6mm i.d.with UV detection at 239 nm. The mobile phase contained ACN: phosphate buffer (pH 3.0) (20:80v/v). The mobile phase was run isocratically. The flow rate of the mobile phase was maintained at 1.0 ml/min. The linearity of the calibration curve was obtained in the concentration range of 5 to 20 µg/ml and coefficient of determination (R2) was found to be 0.9991. The % RSD value for intraday and interday precision was below 2 which indicated that the method was precise. Limit of detection and limit of quantification were 0.416 and 1.324µg/ml respectively. Forced degradation studies were performed under different conditions.
"Determination of Citalopram by RP-HPLC & it’s stability indicative studies", TIJER - TIJER - INTERNATIONAL RESEARCH JOURNAL (www.TIJER.org), ISSN:2349-9249, Vol.11, Issue 2, page no.a540-a545, February-2024, Available :https://tijer.org/TIJER/papers/TIJER2402068.pdf
Volume 11
Issue 2,
February-2024
Pages : a540-a545
Paper Reg. ID: TIJER_151298
Published Paper Id: TIJER2402068
Downloads: 000274
Research Area: Pharmacy All
Country: MAHBUBNAGAR, TELANGANA, India
ISSN: 2349-9249 | IMPACT FACTOR: 8.57 Calculated By Google Scholar | ESTD YEAR: 2014
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.57 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: TIJER (IJ Publication) Janvi Wave
