CRITICAL ANALYSIS OF SUSTAINED RELEASE METFORMIN FORMULATIONS
Ajay Zagade
, Sarth Kurhe , Sanjay Gaikwad , Dr.Sagar Muley
Metformin, sustained release, diabetes, hyperglycemia.
Sustained-release (SR) tablets are recommended to improve patient compliance when taking metformin, which is now sold as a hydrochloride salt in the United States and other countries. Unfortunately, some patients find it difficult to swallow this large SR tablet because of its high water solubility and the high dose needed for efficacy. In order to overcome these obstacles, modifications were made to the salt production, which also affected its solubility. Metformin succinate was selected from among ten newly synthesized medicinal salts due to its decreased molecular weight and solubility. Metformin HCl and succinate were shown to be distinct substances by DSC thermograms and FT-IR spectra. Nonetheless, there was no statistically significant difference observed in other tablet parameters that are associated with effectiveness, such as permeability, density, compressibility, particle size distribution, and stability in different artificial human fluids. In this study, metformin HCl SR tablets and metformin succinate SR tablets with an excipient component lowered from 43% to 14% were created.
"CRITICAL ANALYSIS OF SUSTAINED RELEASE METFORMIN FORMULATIONS", TIJER - TIJER - INTERNATIONAL RESEARCH JOURNAL (www.TIJER.org), ISSN:2349-9249, Vol.11, Issue 2, page no.a197-a208, February-2024, Available :https://tijer.org/TIJER/papers/TIJER2402023.pdf
Volume 11
Issue 2,
February-2024
Pages : a197-a208
Paper Reg. ID: TIJER_150981
Published Paper Id: TIJER2402023
Downloads: 000282
Research Area: Pharmacy All
Country: Beed, Maharashtra , India
ISSN: 2349-9249 | IMPACT FACTOR: 8.57 Calculated By Google Scholar | ESTD YEAR: 2014
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.57 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: TIJER (IJ Publication) Janvi Wave
