“Isolation and Identification of Aspergillus terreus and Production of Lovastatin”

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Monal Ingawale
Nilesh Hiwale
Mansi Mali
Dr.Mukesh Tiwary
Dr.Mohan Waman


          Statins are the secondary metabolites which are produced by some fungal strains and are widely employed for reducing elevated levels of cholesterol in blood plasma Lovastatin is a potent drug was the first statin accepted by United States Food and Drug Administration (USFDA) in 1987 as a hypercholesterolemic drug .Lovastatin, a naturally occurring secondary metabolite is commonly found in foods such as red yeast rice, oyster mushroom, and Pu-erh, although in low concentration, and is primarily used for the cure of dyslipidemia and the prevention of heart-associated diseases as well. Lovastatin is also produced by some specific higher fungi such as Aspergillus terreus, Pleorotus ostreatus, and closely associated Pleorotus species. Production of lovaststin was done by using solid state fermentation by using wheat  bran and rice bran .Maximum yield was obtained when  wheat bran was used as a substrate.


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How to Cite
Ingawale, M., N. Hiwale, M. Mali, D. Tiwary, and D. Waman. “‘Isolation and Identification of Aspergillus Terreus and Production of Lovastatin’”. Technix International Journal for Engineering Research, vol. 9, no. 8, Aug. 2022, pp. 49-64, https://tijer.org/index.php/tijer/article/view/305.
Research Articles


• A. seenivasan, s. subhagar, r. aravindan* and t. viruthagiri Microbial Production and Biomedical

Applications of Lovastatin Biochemical Engineering Laboratory, Department of Chemical Engineering,

Annamalai University, Annamalai Nagar-608 002, India

• Donald F. Gerson, Xinfa Xiao, “Process for the production of lovastatin using Coniothyrium fuckelii.”

U.S. Patent US5409820, issued January, 1984.Donald F. Gerson, Xinfa Xiao, “Process for the

production of lovastatin using Coniothyrium fuckelii.” U.S. Patent US5409820, issued January, 1984.

• Hassan hajjaj,* peter niederberger, and philippe duboc Nestle Lovastatin Biosynthesis by Aspergillus

terreus in a Chemically Defined Medium Research Center, Nestec Ltd., Vers-chez-les-Blanc, CH-1000

Lausanne 26,Switzerland

• Hedayati, M.T.; Pasqualotto, Warn; Bowyer, Denning (2007) “Aspergillus flavus: human pathogen,

allergen and mycotoxin producer”. Journal of Medical Microbiology. 153 (6): 1677-1692.

doi:10.1099/mic.0.2007/007641-0. PMID 17526826. Retrieved 9 November 2013.

• M. Bizukojc E S. Ledakowicz The morphological and physiological evolution of Aspergillus terreus

mycelium in the submerged culture and its relation to the formation of secondary metabolites Received: 1

December 2008 / Accepted: 28 July 2009 / Published online: 9 August 2009 O Springer

Science+Business Media B.V. 2009.

• PanelH.R.ValeraaJ.GomesaS.LakshmibR.GururajabS.SuryanarayanbD.Kumar, Lovastatin production by

solid state fermentation using Aspergillus flavipes Department of Biochemical Engineering and

Biotechnology, Indian Institute of Technology, New Delhi 110016, IndiabBiocon India Ltd., Hosur

Road, Bangalore, Karnataka, IndiacSunPharma Advanced Research Centre, Vadodara, Gujarat, India

• Ravindra H. Patila, Prakash Krishnanb and Vijay L. Maheshwarib Production of Lovastatin by Wild

Strains of Aspergillus terreus,*a Department of Microbiology and Biotechnology, R. C .Patel Arts,

Commerce and Science College, Shirpur 425405 (MS),India b Department of Biochemistry, School of

Life sciences, North Maharashatra University,Jalgaon 425001 (MS), India

• Rashmi Dikshit & Padmavathi Tallapragada Bio-synthesis and screening of nutrients for lovastatin by

Monascus sp. under solid state fermentation Revised: 25 November 2014/Accepted: 8 December 2014

/Published online: 11 February 2015 # Association of FoodScientists & Technologists (India) 2014

• Shi-Weng Li, Hong-Ping Song & Yan Leng To cite this article: Shi-Weng Li, Hong- Ping Song & Yan

Leng (2014) Rapid determination of lovastatin in the fermentation broth of Aspergillus terreus using

dual-wavelength UV spectrophotometry Rapid determination of lovastatin in the fermentation broth of

Aspergillus terreus using dual- wavelength UV spectrophotometry, Pharmaceutical Biology, 52:1, 129-

, DOI: 10.3109/13880209.2013.833947

• Sumel Ashique, Dr. Sachin Tyagi, Raneet Das, Ayan Goswami, Jayita Roy, Mr. Mir Samim Ali, Mr.

Alok Semwal Shashwat Publication, 05-Jan-2022 - Science - 192 pages